Thesis

Investigating the mechanism behind the improved efficacy of hypo-fractionated radiotherapy performed with photons and protons.

• Call:

  ProtoTera Call 2023/1

• Academic Year:

  2023

• Supervisor:

  Joao Seco

• Co-Supervisor:

  Joep Stroom

• Host Institution:

  LIP - Laboratório de Instrumentação e Física Experimental de Partículas

• Granting Degree Institution:

  Instituto Superior Técnico (Universidade de Lisboa)

• Typology:

  Mixed

• Abroad Institution:

  Instituto Superior Técnico (Universidade de Lisboa)

• Abroad Supervisor:

  Pedro Assis

• Abstract:

  The current multi-center PhD project will investigate several possible models to explain why high-fraction dose radiotherapy (SBRT) has higher success rates than conventional radiotherapy. These models are based on variable oxygen or reactive oxygen species (ROS) concentrations within or around the tumor cells. An existing dynamic tumor growth software that uses cell-based modelling will be used to implement and model tumor growth and response to photon and proton radiation. The different SBRT models will be compared for both photons and protons.